Foxp3 expression in bovine CD8sup(+) T cells is associated with the intensity of CD25 expression
2013
Maslanka, T. (University of Warmia and Mazury, Olsztyn (Poland). Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology) | Jaroszewski, J.J.
The aim of the undertaken research was to determine whether Foxp3sup(+)CD25sup(+)CD8sup(+) cells exist in cattle and whether Foxp3 expression in CD8sup(+) T cells is correlated with the intensity of CD25 expression. It has been found that 0.66 and 2.36% of CD8sup(+) cells on average showed high and low expression of the CD25 molecule, respectively. On average, 11.61 % of CD25sup(high)CD8sup(+) cells expressed Foxp3, while the mean percentage of Foxp3sup(+) cells within CD25sup(low)CD8sup(+) cells was 3.66%. The absolute count of Foxp3sup(+)CD25sup(high)CD8sup(+) cells was not significantly different from the absolute count of Foxp3sup(+)CD25sup(low)CD8sup(+) cells. The obtained results indicate that CD8sup(+) cells with the regulatory phenotype, i.e. Foxp3sup(+)CD25sup(high)CD8sup(+) and Foxp3sup(+)CD25sup(low)CD8sup(+) cells, occur naturally in bovine peripheral blood, although both of these subpopulations are relatively small. There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8sup(+) cells.
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