Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation
2019
Jing-Hua Yang | Xin-Yi Wang | Yi-Ping Zhou | Rong Lu | Chin-Ho Chen | Meng-Han Zhang | Yung-Yi Cheng | Susan L. Morris-Natschke | Kuo-Hsiung Lee | Yun-Song Wang
Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3&ndash:8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1&ndash:8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 &mu:g/mL and SI of 7.1.
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