Aphrodisiac potential and preclinical evaluation on the extract of mangrove plants in coastal area of Sabah
2016
Syamimi Khalid | Ana Sharmila Shafie | Mohd Helme Mohd Helan | Thavamanithevi Subramaniam | Joseph Tangah | Lim, Chuan Gee | Ahmad Hazri Ab. Rashid | Aidawati Mohd. Shabery | Nurul Husna Abdullah | Zuleen Delina Fasya Abd. Ghani | Puziah Hashim | John Sugau | Noor Rabihah Aid | Sarifah Rejab
In this study, M. muticus and R. mucronata were chosen for preliminary investigation on aphrodisiac potential using animal model. In materials and methods, The 50% ethanol extract of powder leaf were subjected to chemical profiling, phytochemical analysis, testosterone screening and preclinical evaluation. Preclinical study to access the safety of plant extracts was performed. In vivo investigation of aphrodisiac potentials on the crude extracts was determined by assessing the libido and sexual potency enhancement. From the findings, phytochemical screenings showed the presence of saponins and steroids compound believed to be responsible for aphrodisiac properties. NRU toxicity results were used to estimate the starting dose for acute oral study as well as in vivo efficacy. Under the conditions of this study, the acute oral toxicity of extracts was classified as Category 5 according to the Globally Harmonised System for the classification of chemicals. The LD₅₀ is greater than 2000 mg/kg body weight. The in vivo study has shown that the extract studied significantly increased the serum testosterone level in sexually experienced rats. Sexual desire (libido) and motivation are improved as evidenced by the reduction in mount latency, while sexual performance is enhanced by the reduction of intromission latency.
显示更多 [+] 显示较少 [-]