Inflamacija, oksidativni stres i ketoza kod krava
2020
Delić Vujanović, Biljana | Belić, Branislava | Đoković, Radojica | Staničkov, Nenad | Grubač, Siniša | Petrović, Kosta | Cincović, Marko R.
The peripartal period is a period of intense metabolic stress for dairy animals. Metabolic processes in the peripartum period are controlled by very subtle home-theoretical control mechanisms, in order to adapt the tissue and organs to the needs of the organism in a given period. Oxidative stress in cows in the peripartum period is due to lipid peroxidation. Based on the examination of the oxidative status of high dairy cows in the transition period, it was concluded that the common cause of pathological conditions during this period is a disturbed balance between oxidants and antioxidants, ie. occurrence of oxidative stress. In cows in the peripartum period, a change in plasma lipid concentration has been shown to be associated with lipid mobilization and may affect leukocyte activity and increase disease incidence. Similar studies have shown a decrease in total leukocyte counts in the peripartal period, resulting in a decrease in the body's defense capabilities.30 All of this indicates that inflammation is an important factor in the development of metabolic disorders in cows during the transition period. α (tumor necrosis factor α), as well as interleukin-1 (IL-1), interleukin-6 (IL-6) and interferon-Ƴ (IFN-Ƴ), which are considered essential cytokines to trigger a systemic inflammatory response.TNF- α (tumor necrosis factor-α) reduces the production of glucose in the liver, encouraging at the same time the esterification of fatty acids in the form of triglycerides.
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