Immunogenicity of pasteurella multocida cell associated and cell free antigens in mice
2022
Sahzad | S. Arya | M. Bora | S. Shebannavar | T. V. S. Rao | G. S. Reddy
Haemorrhagic septicaemia is an economically important contagious disease of cattle, buffaloes and bison. In the present study, the efficacy of the vaccines prepared from cell free and cell associated antigens of disease causing organism Pasteurella multocida wasevaluated in mice. From the present study, it was observed that both cell associated and cell free antigens provided protective immunity to the vaccinated animals in combination with each other and increasing the content of both the antigens improved the efficacy of the vaccine blends. In conclusion, use of both cell associated and cell free antigens in vaccine formulations are warranted for developing improved vaccines against Haemorrhagic septicaemia.
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