Clinical effects and morphological lesions after low ochratoxin A levels in broiler chicks
1992
Mraz, A. (Ustav Experimentalnej Veterinarnej Mediciny, Ivanka pri Dunaji (CSFR)) | Kosutzky, J.
Ochratoxin A (OA) was fed to HYBRO broiler chicks at a relatively low level of 850 microgram/kg up to the age of 42 days. The effects of OA on chick development, health state and the patho-morphological lesions in internal organs were investigated in this experiment. The chicks exposed to the relatively low OA levels were observed to lag behind in their growth; this was confirmed by their regular weekly weighing when the lower liveweight in comparison with the control group was recorded from the age of 14 days. A decrease in the liveweight was statistically significant at the age of 21, 28 and 35 days. The patho-anatomic finding was negative. A histological examination of kidneys and liver revealed the pathological lesions typical for ochratoxicosis. The lesions observed included the dystrophy of the tubular epithelial cells, eosinophil granules in the tubulus lumen, dystrophic lesions in the glomerules and cellulization of the connective tissue of intertubular spaces. The lesions of liver indicate allergic responses and defense reactions of the organism to the OA action. On the basis of these results it can be concluded that the relatively low ochratoxin levels cause histopathological lesions in the kidneys and liver of chicks, and in this way they can negatively influence their development and performance.
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