Enantioselective antiphytoviral activity of 1-(alpha-carboxyalkyl)-4,5-dimethyl imidazol-3-oxides in systemically infected host plants
1993
Bauer, U. (Leipzig Univ. (Germany). Dept. of Life Sciences) | Kluge, S. | Nuhn, P. | Stenger, P. | Lettau, H.
1-(alpha-carboxyalkyl)-4,5- dimethyl imidazol-3-oxides were tested as D forms, L forms and racements to their antiviral activity to red clover mottle virus (RCMV) and alfalfa mosaic virus (AVM) in systematically infected host plants. A high enantioselective activity of antiphytoviral compounds was detected. While the D forms reduce the virus content by more than 90%, the L forms do not show any antiviral activity. With a virus-inhibiting activity of 40 to 50%, the racemates are in between these two forms and similar to Virazole. The optimal effective dose is 10(-2) mol x l(-1) for the D forms. Reduced virus concentrations were observed in the systemically infected hosts more than six weeks after application of the compounds. The growth reduction of pea plants caused by the virus infection could be partially abolished by the viral inhibiting activity of the compounds
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