Maturation of insulin and glucose responses to normal feeding in foals [horses]
1993
Smyth, G.B. | Duran, S.H. (Murdoch Univ. (Australia). Dept. of Large Animal Surgery and Medicine) | Young, D.W. (Auburn Univ., Atlanta (USA). Dept. of Physiology and Pharmacology)
Postprandial insulin and glucose concentrations were measured in 3 Arabian and 3 Thoroughbred foals at 1 day, 1 week, 1 month and 3 months of age. Prefeeding serum insulin concentrations were similar in foals at 1 day, 1 week, and 1 month, but had increased significantly to 131 pmol per L at 3 months of age. There was significantly increased serum insulin secretion after a feed in foals at 3 months of age when compared with that at younger ages. Prefeeding serum glucose concentrations ranged from 6.0 mmol per L at 1 day, to 5.9 mmol per L at 1 week, 4.9 mmol per L at 1 month, and 4.4 mmol per L at 3 months of age. There were lower postprandial glucose concentrations with advancing age. It appeared that there was a period of maturation in pancreatic beta-cell function after birth in foals, which reached adult levels of 3 months of age.
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