Comparative pharmacokinetics of iophenoxic acid in cats and brushtail possums
1994
Eason, C.T. | Batcheler, D. | Frampton, C.M. (Manaaki Whenua - Landcare Research, Christchurch (New Zealand))
The comparative plasma pharmacokinetics of iophenoxic acid was studied in the cat and brushtail possum to evaluate the suitability of this compound as a bait marker in these species. In cats, a mean peak plasma concentration of 946 microg per 100 mL was obtained after administration of 1.5 mg per kg of iophenoxic acid. However, at the same dose level in possums, mean peak plasma concentration was only 157 microg per 100 mL. Even after administration of 10 mg per kg of iophenoxic acid, the maximum peak plasma concentration in possums was only 459 microg per 100 mL. The plasma elimination half-life for iophenoxic acid was 107 days in cats and close to one day in possums. Iophenoxic acid is therefore a suitable marker for cats but is unsuitable for use as a long-term quantitative bait marker for possums. Differences between the possum and other mammals in gastrointestinal physiology and plasma protein configuration may account for the poor absorption and rapid elimination of iophenoxic acid in the possum.
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