Selection criteria of Lactobacilli for probiotic use
1997
Nemcova, R. (Ustav Experimentalnej Veterinarnej Mediciny, Kosice (Slovakia))
Lactobacilli belong to the micro-organisms most frequently used to prepare the probiotics. The statement that lactobacilli inhibit the colonization of pathogenic bacteria upon the intestinal epithelium has been confirmed by many experiments on experimental germ-free and/or gnotobiotic animals. The host specificity as well as different degree of the expression of adherent phenotype, which is conditioned, in addition to the effect of the external environment also by the presence of plasmids of adherence, present the important property of the adherence of lactobacilli. The competition for the nutrients to be found on the intestinal epithelium, which present the growth substrates for both the probiotic strains and the pathogens, may present an important factor influencing the colonization of lactobacilli. The inhibitory components of the lactobacilli comprise the production of bacteriocins, toxic metabolites of the oxygen and organic acids.
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