Excision of chromosomal DNA loops by treatment of permeabilised cells with Bal 31 nuclease
1995
Lagarkova, M.A. | Iarovaia, O.V. | Razin, S.V. (Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Gen Biology)
The specificity of long-range fragmentation of human nucleolar genes by Bal 31 nuclease was studied using fractionation of cleavage products by pulsed field gel electrophoresis, followed by Southern hybridization. It was found that limited treatment of permeabilised cells with this nuclease results in accumulation of DNA scissions in matrix attachment areas. Consequently, chromosomal DNA loops and their oligomers are released from the genome.
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书目信息
Molecular and General Genetics (Germany)
卷
249
期
2
ISSN
0026-8925
页码
pp. 253-256
其它主题
Permeabilite; Genero humano
语言
英语
注释
Summary (En)
3 ill.; 18 ref.
类型
Summary
1997-08-15
AGRIS AP
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