PkpA, a novel Phycomyces blakesleeanus serine/threonine protein kinase
1995
Ruiz-Perez, V.L. | Murillo, F.J. | Torres-Martinez, S. (Murcia Univ. (Spain). Facultad de Biologia. Dept. de Genetica y Microbiologia)
This work reports the cloning and sequencing of pkpA, a gene of the filamentous fungus Phycomyces blakesleeanus, whose expression seems to be coupled to vegetative growth. This gene encodes a putative serine/ threonine-specific protein kinase, whose sequence is related to that of the yeast protein STE20, involved in pheromone-response pathways, and to a number of MAPK kinase proteins. However, detailed analysis of the kinase sequence suggests that PkpA is a novel serine/threonine protein kinase that probably participates as an intermediate in an intracellular system controlling nuclear proliferation in P. blakesleeanus.
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