Organization and transcription of the mitochondrial ATP synthase genes in the yeast Yarrowia lipolytica
1995
Matsuoka, M. | Matsubara, M. | Inoue, J. | Kakehi, M. | Imanaka, T. (Osaka Univ. (Japan). Faculty of Engineering. Dept. of Biotechnology)
Mitochondrial gene organization was studied in a dimorphic yeast, Yarrowia lipolytica. The gene order in a sequenced 6.6-kilobase region closely resembles that of the human mitochondrial genome in that ATP synthase subunit 8 and 6 genes are followed by genes for cytochrome c oxidase subunit 3 (which contains an intron), NADH-ubiquinone oxidoreductase subunit 4, and ATP synthase subunit 9. This region also contains tRNA genes decoding AUA, UGA, CUN and CCN codons, suggesting a unique mitochondrial translation. All the above genes are transcribed from the same DNA strand into multigenic RNAs, starting from a nonanucleotide sequence, S'-ATA-TAAATA-3', similar to other yeast mitochondrial promoters.
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