A combined effect of pseudorabies virus growth factor (PRGF) and various cytostatics on tumour (Hep-2) cells in vitro
1997
Kocakova, P. | Golais, F. (Komenskeho Univ., Bratislava (Slovak Republic). Dept. of Microbiology and Virology) | Lesko, J. | Horakova, K.
One of the activities of pseudorabies virus /PRV/ growth factor /PRGF/ is its ability to change the transformed phenotype of cultured tumour cells to the normal one. This activity of PRGF was studied in combination with antiproliferative activity of various cytostatics. An undesirable outcome was observed, when PRGF was combined with 11 out of 12 cytostatics. These cytostatics suppressed the ability of PRGF to change the transformed phenotype of Hep-2 cells, and on the other hand, PRGF diminished the effect of these cytostatics on growth and metabolism (DNA and protein content, glucose consumption, lactate and ammonia production) compared to non-treated control cells.
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