Effect of free and liposomized albendazole on the immune responses in healthy and Toxocara canis - infected mice
1998
Boroskova, Z. | Dvoroznakova, E. | Dubinsky, P. | Velebny, S. | Tomasovicova, O. (Slovenska Akademia Vied, Kosice (Slovak Republic). Parazitologicky Ustav)
The effect of free and liposomized albendazole on the lymphoproliferative activity was studied in healthy and Toxocara canis-infected mice. A replicated administration of drug-free liposomes to healthy mice considerably reduced the response of T and B cells to non-specific polyclonal activators (Concanavalin A, Lipopolysaccharide, Pokeweed mitogen). Liposomes with incorporated albendazole, administered at a dose of 10 mg/kg b.w. twice a day for 5 days, also suppressed the same cell population activity in healthy mice. On the contrary, free albendazole given to healthy animals stimulated their T- and B-cell activity to polyclonal activators. The efficacy of liposomized albendazole against T. canis larvae in the muscles during the myotropo-neurotropic phase of their migration was 41.6 to 60.8 %and in the brain 52.4 to 60.8 %.
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