Pathogenesis of thrombocytopenia in acute classical swine fever
1998
Calderon, N.L. | Fortoul, T.I. | Paasch, L.H. | Bouda, J. (Universidad Nacional Autonoma de Mexico, Mexico City (Mexico))
Ultrastructural evaluations of bone marrow in 16 pigs experimentally infected with the classical swine fever virus and 4 control pigs were performed, in order to determine if classical swine fever virus causes direct damage on platelets or its precursors. A progressive degeneration of megakaryocytes was detected starting at day 1 post infection. The degenerative process ended with necrosis of megakaryocytes. Platelet budding did not present the expected cytoplasmic demarcation and emerging platelets lacked the normal cytoplasmic structure. Since classical swine fever virus particles were observed in degenerated megakaryocytes, it was concluded that megakaryocyte damage caused by classical swine fever virus is responsible for the thrombocytopenia detected in early stages of this disease.
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