Bacterial communication and possible application in control and therapy of bacterial diseases (Review)
2000
Rychlik, I. | Volf, J. | Sevcik, M. (Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic))
Biological processes such as control of bioluminescence in Vibrio fisherii and Vibrio harveyi, expression of virulence factors in Pseudomonas aeruginosa and Erwinia carotovora or conjugative transfer of the Ti plasmid in Agrobacterium tumefaciens are dependent on the production and sensing of specific secondary metabolites derived from the structure of N-acyl homoserine lactone. These metabolites are released and sensed by bacterial populations which in turn modify their metabolism accordingly. Understanding the biological role of this communication could enable specific modification of behaviour of bacterial populations and thus open a way to new therapeutic measures. All of this becomes even more important in a time when antibiotic resistance in bacteria increases and new ways of prevention and control of infectious diseases are sought.
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