[Recent advances and particular aspects of cell-mediated immunity in swine species]
2000
Miduri, F. | Angelis, E. de | Borghetti, P. | Corradi, A. | Cabassi, E. (Parma Univ. (Italy). Istituto di Anatomia Patologica Veterinaria)
The aim of the AA is to study the cell-mediated immunity of swine because of the significant differences found in this species, compared to other mammals. In fact the pig has an inverted linfonodal structure and shows an unusual way of lymphocyte circulation. In addition, it shows a different CD4+/CD8+ ratio in peripheral blood and it also shows the presence of two particular subsets of T lymphocyte: the double positive subset (CD4+CD8+) is unique of swine and it is not detected in significant numbers in other species, The double negative one (CD4-CD8-) is also found in sheep and in cattle. The peripheral blood of pig is characterized by an high proportion of g/d T cells which are able to bind a wide variety of antigens, suggesting that they are of major functional significance. These g/d T cells are very important because they represent the first defensive line against various pathogens and they may also be required to provide an early cell-mediated response in animals whose immunoglobulins fail to cross the placenta (pig, horse). The investigation of the swine immune-system may help human and veterinary experimental researchers; particularly, it can provide helpful indications about the pathogenesis of some important new viral infectious diseases of swine that can interacts dramatically on the cooperation between macrophagic cells and lymphocytic cells (Circovirus)
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