Cytosolic innate immune sensing and signaling upon infection
2016
Radoshevich, Lilliana | Dussurget, Olivier
Cytosolic sensing of pathogens is essential to a productive immune response. Recent reports have emphasized the importance of signaling platforms emanating from organelles and cytosolic sensors, particularly during the response to intracellular pathogens. Here, we highlight recent discoveries identifying the key mediators of nucleic acid and cyclic nucleotide sensing and discuss their importance in host defense. This review will also cover strategies evolved by pathogens to manipulate these pathways.
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书目信息
Frontiers in Microbiology (7), . (2016)
其它主题
Sting; Mavs
语言
英语
类型
Journal Article
2016-06-15
AGRIS AP