AMELIORATIVE EFFECT OF MURRAYA KOENIGII LEAF (CURRY LEAF) ON ADJUVANT INDUCED ARTHRITIS IN WISTAR RATS
2023
H.R. Sushma | N. Jayanthi | N. Pazhanivel | G. Sarathchandra | Ganne Venkata Sudhakara Rao
The different parts of Murraya koenigii leaf are traditionally used for treatment of wide variety of ailments. The present study was designed to evaluate the effect of methanolic extract of curry leaves on growth and haemato-biochemical parameters in adjuvant induced arthritis. Sixty Wistar rats were divided into 6 groups containing ten each (n=10), Group I- Sham control, Group II- Plant extract only, Group III- Complete Freund’s Adjuvant (CFA) only, Group IV- CFA + ibuprofen, Group V- Prophylactic group, Group VI- Therapeutic group. Rheumatoid arthritis (RA) was induced by sub-plantar injection of Complete Freund’s Adjuvant (CFA). The body weight gain and feed intake were measured at weekly intervals upto 28th days and blood was collected on 28 day for haematology and serum biochemistry. The analysis of parameters on body weight, feed intake and haematobiochemistry revealed that curry leaf extract had a considerable effect in preventing and ameliorating the severity of arthritis. Methanolic extract of curry leaves appears to be a promising natural remedy of RA.
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