Effect of Some Agricultural Treatments on Growth, Productivity and the Proportion of Active Substances in the Flowers of Saffron (Crocus sativus L

References 1. Aalizadeh, MB., Makarian, H., Ebadi, A., Eizadi Darbandi, E., & Gholami, A. (2018). Effect of biological and chemical fertilizers on stigma yield and quality of saffron (Crocus sativus L.) in climatic conditions of Ardabil. Iranian Journal of Crop Sciences. 20: 16–29. Ardebil : Iran . Agricultural Research Center of Ardebil. 2. Acar, G., MercanDogan, N., Emin Duru, M., Kıvrak, I. (2010). Phenolic profiles,antimicrobial and antioxidant activityof the various extracts of Crocus species in Anatolia. African Journal of Microbiology Research. 4(11):1154-1161.Kinikli: Turkey. Pamukkale University. 3. Afrazeh, Z., Boland, M., Khorshidi, M., and Mohammadi Nafchi, A.(2014). Evaluation of antioxidant activity of aqueous and alcoholic extracts (methanol,ethanol) saffron petals. Saffron Agronomy & Technology. 2(3): 231-236. Damghan Branch: Iran, Islamic Azad University. 4. Agayev, YM. (2003) .Breeding of saffron (Crocus sativus L.): Possibilities and Problems”. The 1ST International Symposium on Saffron Biology and Biotechnology, lbacete, Esparia, p. 70. 5. Agronomy Statistics. (2020). Jihad Keshavarzi Organization of the South Khorasan province. Birjand, Iran. 6. Akhondzadeh, S., Sabet, MS., Harirchian, M., Togha, M., Cheraghmakani, H., Razeghi, S. (2010). Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16 week, randomized and placebo controlled trial.Journal of Clinical Pharmacy and Therapeutics. 35 (5): 581 - 587. Tehran: Iran. University of Medical Sciences. 7. Akhtar, N., Anjum, T., and Jabeen, R.(2013a). Isolation and identification of storage fungi from citrus sampled from major growing areas of Punjab, Pakistan. International Journal of Agric. Biol. 15: 1283‒1288. Lahore: Pakistan. University of the Punjab. 8. Akhtar, S., Shakeel, S., Mehmood, A., Hamid, A., and Saif, S. (2013b). Comparative analysis of animal manure for soil conditioning. International Journal of Agronomy and Plant Production. 4(12): 3360-3365. Punjab: Pakistan. Environmental Sciences. 9. Alavi Shahri, H., Mohajeri, M., Folaki, M.A. (1994). Evaluation of plant density (planting distanse) on saffron yield. Proceedings of 2nd Meeting of Saffron and Medicinal Plant Agronomy. Gonabad, Iran. 10. Alavi Siney, SM., Jolgeh, A.,A Behroozeh, M and Soltani, M .(2022)..Effect of corm transfer date and maternal corm weight on qualitative traits and yield of saffron in Jiroft condition. Iranian Journal of Field Crop Science.25(4):211-221. Kerman: Iran.South Kerman Agricultural-Jihad of Jiroft.11. Ali Ahmad, L., Sorooshzadeh, A., & Mokhtassi Bidgoli, A. (2017). Studying the possibility of saffron vertical culture system (Crocus sativus L. ). Saffron Agronomy & Technology. 5:161–173. Tehran: Iran. University of Tarbiat modares. 12. Alipoor, M., Zeinab, M., Sohrab, B., Mohammad A., and Sayyari, M H. (2014). Effect of manure, bio-and chemicalfertilizers and corm size on saffron (Crocus sativus L.) yield and yield components. Journal of Saffron Research. 1(2):73-84.Birjand:Iran.University of Birjand. 13. Amini, J., and Sidovich, D.(2010). The effects of fungicides on Fusarium oxysporum f. sp. Lycopersici associated with fusarium wilt of tomato. Journal of Plant Protection on Research. 50(2):172-173. Sanandaj:Iran. University of Kurdistan. 14. Aminifard, M H., and Ahmadi, F. (2019). Effects of fulvic acid and cow manure on stigma active components and petal antiradical activity of saffron (Crocus sativus L.). Saffron Agronomy & Technology. 6(4): 415-428.Birjand: Iran. University of Birjand. 15. Aminifard, MH., and Gholizade, Z. (2017) . Impact of chicken manure on vegetative criteria and photosynthetic pigments of saffron (Crocus sativus L.).Agricultural plant science., Iran.1:1-12. Birjand: Iran. University of Birjand. 16. Amirghasemi, T. (2001). Saffron, Red Gold of Iran. Nashr Ayandegan Publication. 112 pp. 17. Amiri, MB., & Esmaeilian, Y. (2019). Study of flower and corm quantitative characteristics of saffron (Crocus sativus L.) under organic, biological, and chemical nutrition. Saffron Agronomy & Technology.7(1):27–40. Gonabad, Iran, University of Gonabad. 18. Amirshekari, H., Sorooshzadeh, A., Modarress Sanavy, A., Jalali Javaran, M.( 2007). Study of effects of root temperature, corm size, and gibberellin on underground organs of saffron (Crocus sativus L.). J. Biol. (19): 5–18.Tehran: Iran. University of Tarbiat modares. 19. Amoon, A., Ramah, H., and Radmehr, A.(2013).Response of saffron (Crocus sativus L.) to organic animal manure application. International Journal of Manures and Fertilizers. 2(7):349-351.Tabriz : Iran. University of Tabriz. 20. Andabjadid, S S., Eslam, B., Pasban , B., Amir Reza, S., and Mohammadi, H.(2015). Effects of corm size and plant density on Saffron (Crocus sativus L.) yield and its components.International Journal of Agronomy and Agricultural Research.6(3):20-26.Tabriz: Iran.University of Azerbaijan Shahid Madani. 21. Anitha, A., and Rabeeth, M.(2009). Control of fusarium wilt of tomato by bioformulation of Streptomyces griseus in green house production. African Journal of Basic and AppliedSciences. (1):9-14. Tamil Nadu: India. Kongunadu College. 22. Assimopoulou, A., Sinakos, Z., and Papageorgiou, V.(2005). Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytotherapy Res. 19 (11):997 - 1000. Thessaloniki: Greece. University of Thessaloniki23. Aytekin, A., and Acikgoz, A.O. (2008). Hormone and Microorganism Treatments in the Cultivation of Saffron (Crocus Sativus L.) Plants. Molecules. 13(5): 1135-1146. Bartin: Turkey. Bartin Foresty Faculty. 24. Azizi-Zohan, A. A., Kamgar-Haghighi, A. A., and Sepaskhah, A. R. (2004). Investigation on water requirement, irrigation method and frequency of saffron (Crocus sativus L.). Sci. Technol. Agric. Nat.Resour. 10:45-54. Shiraz: Iran. University of Shiraz. 25. Bagherzade, G., & Manzaritavakoli, M. (2016). Qualitative and Quantitative Investigation of Phytochemical Factors of Wastage of Crocus Sativus L. and Determination of Anthocyanin Content using Ultrasound Waves. Journal of Saffron Research. 4(2): 149-158. Birjand: Iran. University of Birjand. 26. Basti, A.A., Moshiri, E., Noorbala, A.A., Jamshidi, A.H., Abbasi, S.H., and Akhondzadeh, S. (2007). Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: a pilot double-blind randomized trial. Prog. Neuro-Psychopharmacol. Biol.Psychiatry. 31(2): 439-442. Tehran: Iran. University of Tehran. 27. Booth, C.(1984). The Fusarium problem: Historical, economic, and taxonomic aspects. The Applied Mycology of Fusarium.1-13. Cambridge: Britain. Cambridge University. 28. Boubaker, H., Saadi, B., Boudyach, H., and Benaoumar, A.(2009). Sensitivity of Penicillium digitatum and P. italicum to Imazalil and Thialbendazole in Morocco. Plant Pathology Journal. 8(4):152-158.Agadir: Morocco.Ibn Zohr University. 29. Chaji, N., Khorassani, R., Astaraei, AR., & Lakzian, A. (2013). Effect of phosphorous and nitrogen on vegetative growth. Journal of Saffron Research. 1(1): 1-12. Mashhad: Iran.Ferdowsi University of Mashhad. 30. Chen, K., Wang, X., Chen, F., and Bai, J.(2017). In vitro antimicrobial and free radical scavenging activities of the total flavonoid in petal and stamen of Crocus sativus. Indian J. Pharm. Sci. 79: 482–487. Chengdu: China. Sichuan University. 31. Chen, S.; Wang X.; Zhao, B. and Wang, Y.(2004). Screening of Crocus sativus L. callus lines for crocin production, Chinese Bulletin of Botany, 21(4): 455-460. 32. Chen, Y., and Aviad, T.(1990). Effect of Humic Substances on Plant Growth. In:P.,Maccarthy, P Ed., Humic Substances in Soil and Crop Sciences: Selected Readings. American Society of Agronomy and Soil Sciences, Madison. 161-186. 33. Chichiriccò, G. (1999). Sterility and perspectives for genetic improvement of Crocus sativus L., in: Negbi M. (Ed.), Saffron, Harwood Academic Publishers, Amsterdam, pp. 127–135. 34. Chichiriccò, G., Lanza, B., Piccone, P., and Poma, A.(2016). Nutrients and heavy metals in flowers and corms of the Saffron Crocus (Crocus sativus L.). Med. Arom. Plants. 5, 4:1-5. L’Aquila: Italy. University of L’Aquila.35. Christaki, E., Bonos, E., Giannenas, I., and Florou-Paneri, P.(2012). Aromatic Plants as a source of bioactive compounds. Agriculture. 2: 228-243. Thessaloniki: Greece. University of Thessaloniki. 36. Coleman, D.C., D.A. Crossley and P.F. Hendrix. (1996). Fundamentals of Soil Ecology, pp: 48‒77. Academic Press, London. 37. Delgado, MC., Aramburu, AZ., Diaz-Marta, GLA. (2006). The Chemical Composition of Saffron: Color Taste and Aroma Imprenta Junquera S.L. Albacete. pp. 1-213. 38. Didaras, N., Karatasou, K., Dimitriou, T., Amoutzias, G., and Mossialos, D.(2020). Antimicrobial Activity of Bee-Collected Pollen and Beebread: State of the Art and Future Perspectives. Antibiotics. 9(811): Volos: Greece. University of Thessaly. 39. Dimond, AE., Davis, D., Chapman, RA., and Stoddard, EM. (1952). Plant chemotherapy as evaluated by the Fusarium wilt assay on tomato. The Connecticul Agric. Exp. St. Bulletin. 557. 40. Domsch, KH., and Gams,W.(1980).Compendium of soil fungi. California.Warner press. 1229 p. 41. Douglas, M.H., Smallfield, B.M., Wallace, A.R., McGimpsey, J.A.(2014). Saffron (Crocus sativus L.), The effect of mother corm size on progeny multiplication, flower and stigma production. Sci. Hortic., 166: 50–58. Clyde: Newzealand. Redbank Research Station. 42. Fahim, N., Janati, S., and Feizy, J.(2012). Chemical composition of agriproduct saffron (Crocus sativus L.) petals and its considerations as animal feed. Giad J Food .37:197-201. Rasht: Iran. University of Guilan. 43. Falck, R. (1907). Walchstumesetze, Wachstumtaktoren und temperature wertter Holzerstercn-den. Mycelien., 1 :153-154. Himachal Pradesh: India. University of Horticulture and Foresty. 44. Fallahi, HR., and Mahmoodi, S.(2018). Influence of organic and chemical fertilization on growth and flowering of saffron under two irrigation regimes. Saffron Agronomy & Technology. 6(2): 147- 166. Birjand: Iran. University of Birjand. 45. Fallahi,H.R., Shajari, M.A., Sahabi, H, Behdani,A., and Vatandoos, S. (2021).Influence of some pre and postharvest practices on quality of saffron stigmata. Scientia Horticulturae, 278(27):109-146. Birjand: Iran University of Birjand,. 46. Farag, M., Hegazi, N., Dokhalahy, E., Khattab, A.(2020). Chemometrics based GC-MS aroma profiling for revealing freshness, origin and roasting indices in saffron spice and its adulteration. Food Chem.;331:127358.1-18.Cairo: Egypt. Cairo university. 47. Fatehi, M., Rashidabady, T., Fatehi-Hassanabad, Z.(2003). Effects of Crocus sativus petals’ extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum. J. Ethnopharmacol. 84(2):199-203. Mashhad: Iran. Mashhad University48. Fernández, J.A. (2004). Biology, biotechnology and biomedicine of saffron, Recent Res. Dev. Plant Sci. 2: 127–159. Albacete: Spain. Castilla-La Mancha University. 49. Ghalavand, A., & Abdollahian, M. (1994). Ecological adaptation and study of spacing and method of planting on yield of different landraces of Iranian saffron. Proceedings of 2nd Seminar on Saffron and Cultivation of Medicinal Plants. Gonabad:Iran. 50. Ghanbari, J ., Khajoei-Nejad, G., Erasmusa , S W., and Rutha, S.M.V. (2019). Identification and characterisation of volatile fingerprints of saffron stigmas and petals using PTR-TOF-MS: Influence of nutritional treatments and corm provenance. Industrial Crops & Products. 141. Kerman: Iran. University of Kerman. 51. Ghobadi, F., Ghorbani Javid,M., Sorooshzadeh,A.(2016). Evaluation of yield and growth characteristics of saffron (Crocus sativus L.) under effect of planting date and corm size in Varamin plain. Iranian Journal of Medicinal and Aromatic Plants. 32( 5):857-867. Pakdasht: Iran. University of Tehran. 52. Ghorbani, R., & Koocheki, A. (2007). Organic saffron in Iran: prospects challenges. Proceedings of the 2nd International Symposium on Saffron. Biology and Technology. 369-384.Mashhad: Iran.Ferdowsi University of Mashhad. 53. Gil, M.I., Tomás-Barberán, F.A.,Hess-Pierce, B., and Kader, A.A. (2002). Antioxidant capacities, phenolic compounds،carotenoids, and vitamin C contents of nectarine, peach, and plum cultivars from California. Journal of Agricultural and Food Chemistry. 50(17): 4976-4982. California: USA. University of California. 54. Goli, S.A.H., Mokhtari, F., and Rahimmalek, M. (2012). Phenolic compounds and antioxidant activity from saffron (Crocus sativus L.) petal. J Agric Sci. 4:175–181. Isfahan: Iran. Isfahan University of Technology. 55. Gonabad, H. (2013). Caratterizzazione morfologicae molecolaredello zafferano (Crocus sativus L.) iraniano (Khorasan). Tesi di Dottorato di Ricerca. UniversitàdegliStudi di Perugia. 56. Gresta, F., Lombardo, GM., Siracusa, L., and Ruberto, G. (2009). Saffron, an alternative cropfor sustainable agricultural systems. A review.Agronomy for Sustainable Development. 28:95-112. Catania: Italy. Università di Catania. 57. Hadizadeh, F., Naaman, K., Hosseinzadeh, H., and Randa, K-A.(2003). Kaempferol from saffron petals. Iran J Pharm . 2:251-252. Mashhad: Iran. Mashhad University. 58. Hammami, H., Jahani, M., Shoshtari, M., and Noferesti, F.(2020). Evaluation of Allelopathic and Antifungal Effects of Different Concentrations of Aqueous Leaves and Corm Extracts of Saffron (Crocus sativus L.) on Common Purslane and Penicillium sp. Journal of Saffron Research. 8(2): 255-267. Birjand: Iran. University of Birjand. 59. Hamood Al-Saeedi, A., and Amzad Hossain, M. (2015). Total phenols, total flavonoids contents and free radical scavenging activity of seeds crude extracts of pigeon pea traditionally used in Oman for the treatment of several chronic diseases.Asian Pac. J. Trop. Dis. 5 (4): 316–321. Nizwa: Oman. University of Nizwa.60. Hassan-Beygy, R., Ghanbarian, D., Kianmehr, M.H., and Farahmand, M.(2010).Some physical properties of saffron crocus corm. Cercetări Agronomice în Moldova, XLIII(1)-(141):17-28. Tehran: Iran. University of Tehran. 61. Hassanzadeh Aval, F., Rezvanimoghaddam, P., Bannayanaval, M., & Khorasani, R. (2013). Effects of maternal corm weight and different levels of cow manure on corm and flower yield of saffron (Crocus sativus L.). Saffron Agronomy & Technology.1(1): 22-39. Mashhad: Iran. Ferdowsi University of Mashhad. 62. Hayes, M., and Edward, C. (2001). Humic Substances of compositions, aspects of structure and environment influences. J. Soil Sci. 166 (11): 723-737.Limerick: Ireland. University of Limerick. 63. Holland, A. (2008). Traning Manual Saffron. Organic Agriculture:322–358 64. Hossein, G., Sayed, A., Mokhtari, F., and Rahimmalek, M.(2012). Phenolic compounds and antioxidant activity from saffron (Crocus sativus L.) petal. J Agric Sci .4:175-181. Isfahan: Iran. Isfahan University. 65. Hosseini, A., Razavi, BM., and Hosseinzadeh, H.(2018). Saffron (Crocus sativus) petal as a new pharmacological target: a review. Iran J Basic Med Sci . 21:1091-1099. Mashhad: Iran. Mashhad University of Medical Sciences. 66. Hosseini, S.M., Sorooshzadeh, A., and Modares Sanavi, S.A.M.(2015). Effects of substrate culture, axillary bud removing and mother corm size on daughter corm production and morphological traits in the saffron plant (Crocus sativus L.). Iranian Journal of Medicinal and Aromatic Plants. 31(2):194-203. Tehran: Iran. Tarbiat Modares University. 67. Hosseinzadeh, H., and Khosravan, V.(2002a). Anticonvulsant effects aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice. Arch. Irn. Med. 5: 44-47. Mashhad: Iran. Mashhad University. 68. Hosseinzadeh, H., and Younesi, H.M. (2002b). Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol .2(1):1-8. Mashhad: Iran. Mashhad University. 69. Husaini, A., Bhat, M.A., Kamili, A., and Mir, M.A. (2013). Kashmiri Saffron in Crisis. Sciences, 104(2):323-33. Kashmir, India. University of Agricultural Sciences and Technology of Kashmir. 70. Hye Ji, S., Kwang Kim, T., Keum, Y., and Chun, Se-C . (2018). The Major Postharvest Disease of Onion and Its Control with Thymol Fumigation During Low-Temperature Storage. Mycobiology. 46:(3) 242-253. Seoul: Republic of Korea. Konkuk University. 71. Ismaeili, V., Moradi, P., & Ansari, Kh. (2015). Changes of crocin, picrocrocin and safranal in saffron (Crocus sativus L.) treated with compost and biological fertilizations. The first national conference on the use of medicinal plants and traditional medicine in life style. 46-49. University of Torbat Heidariyeh. 72. ISO 3632-1-1993, Saffron (Crocus sativus L.) Part 1:Specifications, International Organisation for Standardization, Geneva.73. ISO 3632-2010, Saffron (Crocus sativus Linneaus): Test methods, International Organisation for Standardization, Geneva. 74. Jadouali, S.M., Atifi, H., Bouzoubaâ, Z., Majourhat, K., Gharby,S., Achemchem, F., Elmoslih,A., Laknifli, A., and Mamouni, R.(2018). Chemical characterization, antioxidant and antibacterial activity of Moroccan Crocus sativus L petals and leaves. Journal of Materials and Environmental Sciences. 9(1):113-118. Agadir: Morocco. University Ibn Zohr. 75. Jadouali, S.M., Atifi, H., Mamouni, R., Majourhat, K., Bouzoubaâ, Z., Laknifli,A., and Faouzi, A. (2019). Chemical characterization and antioxidant compounds of flower parts of Moroccan Crocus sativus L. Journal of the Saudi Society of Agricultural Sciences. 18 : 476–480. Agadir: Morocco. University Ibn Zohr. 76. Jahan, M., and Jahani, M. (2007). The Effects of Chemical and Organic Fertilizers on Saffron Flowering. Acta Hort. 739: 81-86. Mashhad: Iran.Ferdowsi University of Mashhad. 77. Jassemi, K., Kardoni, F., and Ali Behdani, M. (2011). The study of various fertilizers use and their effects on yield in the saffron fields.The first Iranian Fertilizer Challenges Congress. Half a Century Fertilizer Consumption. 1-12. Birjand: Iran .Birjand University. 78. Juan, JAD., Córcoles, HL., M-Munoz, R., & Picornell, M. (2009). Yield and yield components of saffron under different cropping systems. Industrial Crops Prodction. 30(2): 212–219. Albacete: Spain. Castilla-La Mancha University. 79. Kafi, M., Kakhki, A. H., and Karbasi, A.(2006). Historical Background, Economy, Acreage, production, yield and uses. Science Publisher. Enfield. p.1-12. Mashhad:Iran. University of Mashhad. 80. Kafi, M., Rashed, M., Mohammad, H., Koocheki, A., and Mollafilabi, A.(2002). Saffron,Production and Processing. 276 pp. Mashhad: Iran.Ferdowsi University of Mashhad Press. 81. Karasawa, K. (1933). On the triploidy of Crocus sativus L. and its high sterility. Jpn J Genet. 9(1): 6-8. Tokyo: Japan. Biological Institute. 82. Karimi, E., Oskoueian, E., Hendra, R., Z.E. Jaafar,H. (2010). Evaluation of Crocus sativus L. Stigma Phenolic and Flavonoid Compounds and Its Antioxidant Activity. J. Molecules. 15(9):6244-6256. Selangor: Malaysia. Universiti Putra Malaysia. 83. Khalid, A.Kh., Hendawy, S.F., and El-Gezawy, E. (2006). Ocimum basilicum L. Production under Organic Farming. Research Journal of Agriculture and Biological Sciences. 1: 25-32.Cairo: Egypt. National Research Center. 84. Khan, MA., Nagoo, S., Naseer, S., Lone, AA., Nehvi, FA. (2010). Effect of Fertilizers Foliar Application on Nitrogen and Phosphorus Uptake of Saffron (Crocus sativus). Industrial Crops and Products.Not Sci Biol.8(4):461-467. Kuala Lumpur: Malaysia. Kuala Lumpur University. 85. Khazaei, K., Mahdavi, J., Seid, M, Ghorbani, M., Kakhki, AH., and Sarfarazi, M.(2016). Optimization of anthocyanin extraction from saffron petals with responsesurface methodology. Food Anal Methods. 9:1993-2001. Gorgan: Iran. Golestan University. 86. Kianimanesh, K., Lebaschi, MH., Jaimand, K., Abdossi, V., and Tabaei-Aghdaei, SR.(2021).Evaluating the Application of Organic and Chemical Fertilizers for Safranal, Crocin, and Picrocrocin of Saffron (Crocus sativus L.) under Dryland Farming System. Journal of Medicinal Plants and By-products.1-8. Tehran: Iran.Islamic Azad University. 87. Koocheki, A and Seyyedi, S. M. (2016). Effects of Corm Size, Organic Fertilizers Foliar Application on Nitrogen and Phosphorus Uptake of Saffron (Crocus sativus). Industrial Crops and Products.Not Sci Biol.8(4):461-467. Mashhad:Iran. Ferdowsi University of Mashhad. 88. Koocheki, A., and Seyyedi, S.M. (2015). Phonological stages and formation of replacement corms of saffron (Crocus sativus L.) during growing period. Journal of Saffron Research. 3(2): 134-154. Mashhad:Iran. Ferdowsi University of Mashhad. 89. Koocheki, A., Fallahi, H.R., Amiri, M.B., and Ehyaei, H.R. (2016). Effects of humic acid application and mother corm weight on yield and growth of Saffron (Crocus sativus L.). Journal of Agroecology. 7(4): 425-442. Mashhad:Iran. Ferdowsi University of Mashhad. 90. Koocheki, A., Ganjeali, A., and Abbassi, F. (2007). The effect of duration of incubation and photoperiod on corm and shoot characteristics of saffron plant (Crocus sativus L.). Acta Hortic. 739, 61-70. Mashhad: Iran. Ferdowsi University of Mashhad. 91. Koocheki, A., JahaniM Tabrizi, L., & Mohammadabadi, AA. (2011). Investigation on the Effect of Biofertilizer, Chemical Fertilizer and Plant Density on Yield and Corm Criteria of Saffron (Crocus sativus L.). Journal of Water and Soil. 25(1): 196-206. Mashhad:Iran. Ferdowsi University of Mashhad. 92. Koocheki, A., Nassiri Mahallati, M., Alizadeh, A., Ganjali, A. (2010). Modelling the impact of climate change on flowering behaviour of Saffron (Crocus sativus L.). Iran. J. Field Crop Res. 7:(2) 583–594. Mashhad:Iran. Ferdowsi University of Mashhad. 93. Kumar, R., Singh, V., Devi, K., Sharma, M., Singh, M.K., and Ahuja, P.S.(2009). State of art of saffron (Crocus sativus L.) agronomy: a comprehensive review. Food Rev, Int, 25: 44–85.Palampur: India. Institute of Himalayan Bioresource Technology. 94. Lashay ,A., Sadough ,G., Ashrafi ,E., Lashay .M., Movassat , M., and Mancha, A.(2016) .Short-term out comes of saffron supplementation in patients with age-related macular degeneration: a double-blind, Placebo-controlled, Randomized Trialed. Medical hypothesis discovery and innovation ophthalmology. 5(1):32-38. Tehran: Iran. Tehran University of Medical Sciences. 95. Manzo, A., Panseri S., Bertoni D., and Giorgi, A.(2015). Economic and qualitative traits of Italian Alps saffron. Journal of Mountain Science.12(6): 1542-1550. Brescia: Italy. Università degli Studi di Milano.96. Mardani Asl, SA., Dehnavi, MM., Salehi, A., and Yadavi, A.(2018). Effects of Corm Weight and Planting Density on Saffron (Crocus sativus L.) Yield under the Canopy of Apple Tree. Journal of Saffron Research.6:(1) 89-102. Yasouj: Iran. Yasouj University. 97. Martos, V., Navajas, R., Lopezi, F., and Alvarez, P.(2007). Antifungal activity of thyme , clove and oregano essential oils. J Food Safety. 27: 91-101. Orihuela: Spain. Universidad Miguel Hernández. 98. Mathew, S., and Abraham, T.E. )2006(. In vitro antioxidant activity and scavenging effects of Cinnamomum verum leaf extract assayed by different methodologies. Food and Chemical Toxicology. 44: 198-206. 99. Mc-Gimpsey, JA., Douglas, MH., and Wallace, AR. (1997). Evaluation of saffron (Crocus sativus L.) production in New Zealand. New Zealand Journal of Crop and Horticulture Sciences. 25: 159-168.Clyde, New Zealand.New Zealand Institute for Crop and Food. 100. Menia, M., Iqbal, S., Zahida, R., Tahir, S., Kanth, Rh., Saad, A., & Hussian, A. (2018). Production technology of saffron for enhancing productivity. Journal of Pharmacognosy and Phytochemistry. 7:1033–1039. Kashmir, India. Kashmir University of Agricultural. 101. Meraji, HS. , Mohammadi, M., Salek Seyfi, K. , Hazbipour, S., and Moradi, M .(2018). Control of two species of fusarium fungi by medicinal plants. Plant Protection Journal. 9(1): 45-58.Shiraz: Iran. Islamic Azad University. 102. Mir, M., Rameashkannan, M., Raj, J., Malik, A., Rajesh, T.(2018). Phytochemical and pharmacological profile of Crocus sativus L. by-products found in Kashmir. Acta Hortic. 1200: 213–225. Tamil Nadu: India. Bharathidasan University. 103. Mohamad-Abadi, AA., Rezvani-Moghaddam, P., & Sabori, A. (2007). Effect of plant distance on flower yield and qualitative and quantitative characteristics of forage production of saffron (Crocus sativus L.) in Mashhad conditions. Acta Horticulturae (ISHS). 739:151-153. Mashhad:Iran. Ferdowsi University of Mashhad. 104. Molina, R.V., García-Luis's, A., Coll's, V., Ferrer's, C. (2004). Flower formation in the saffron crocus (Crocus sativus L). The role of temperature. Acta Horticulturae, 650(2):39-47. Valencia, Spain, Universidad Politécnica. 105. Molina, R.V.; Valero, M.; Navarro, Y.; Garcia-Luis, A. and Guardiola, J.L.(2005). Temperature effects on flower formation in saffron (Crocus sativus L.). Scientia Horticulturae. ,103(3): 361-379. Valencia, Spain, Universidad Politécnica. 106. Mollafilabi, A, and Korramdel, S. (2016). Effects of cow manure and foliar spraying on agronomic criteria and yield of saffron (Crocus sativus L.) in a six year old farm. Saffron Agronomy and Technology. 3 (4): 237-249.Mashhad: Iran. Ferdowsi University of Mashhad.107. Mollafilabi, A. (2004). Experimental findings of production and echo physiological aspects of Saffron (Crocus sativus L.). Acta Horticulturae. 650:195–200. Mashhad: Iran. Ferdowsi University of Mashhad. 108. Mollafilabi, A., Koocheki, A., Moghaddam, PR., & Nassiri, M. (2014). Effect of plant density and corm weight on yield and yield components of saffron under soil, hydroponic and plastic tunnel cultivation. Saffron Agronomy & Technology. 1:14–28. Mashhad: Iran. Ferdowsi University of Mashhad. 109. Mortazavi, S.M., Kamali , M., Safi, S.M., and Salehi, R.(2012). Saffron Petals, By-Product for Dyeing of Wool Fibers. Prog. Color Colorants Coat. 5: 75-84. Isfahan: Iran. Isfahan University of Technology. 110. Mousavi, SH., Afshari, JT., & Brook, A.(2008). Study of Cytotoxic Effects of Saffron in MCF-7 Cells. Iranian Journal of Pharmaceutical Sciences. 4(4): 261-268. Mashhad.Iran. Mashhad University of Medical Science. 111. Muzaffar, S, Rather, S and Zaman Khan, K.(2016). In vitro bactericidal and fungicidal activities of various extracts of saffron (Crocus sativus L.) stigmas from Jammu & Kashmir, India, Cogent Food and Agriculture. 2( 1158999):1-7. Srinagar: India. University of Kashmi. 112. Naghdibadi, H.A.; omidi H.; golzad A.; torabi H. and fotoukian M.H. (2011).Change in crocin, safranal and picrocrocin content and agronomical characters of saffron (Crocus sativus L.) Under biological and chemical of phosphorous fertilizers .Journal of medicinal plants , 10 ( 40) :58- 68.Tehran.Iran. University of Shahed. 113. Nakhaei, M, Khaje-karamoddin, M and Ramezani, M.(2008). Inhibitation of Helicobacter pylori growth in vitro by saffron (Crocus sativus L.). Iran j basic Med sci. 11(2):91-96. Mashhad:Iran. University of Mashhad. 114. Nan, Wu., Kuang, Fu., Yu-Jie, Fu., Yuan-Gang, Zu., Fang-Rong. Chang, Yung-Husan, Chen., Xiao-Lei, Liu., Yu, Kong., Wei, Liu., and Cheng-Bo,Gu.(2009). Antioxidant Activities of Extracts and Main Components of Pigeonpea [Cajanus cajan(L.)Millsp.] Leaves. Molecules. 14(3): 1032-1043. Harbin: China. Northeast Forestry University. 115. Nassiri M., A. Koocheki, Z. Boroumand Rezazadeh, L. Tabrizi.(2008) Effects of corm size and storage period on allocation of assimilates in different parts of saffron plant (Crocus sativus L.). Iranian Journal of Agricultural Research. 5:(1).155-166. Mashhad:Iran. Ferdowsi University of Mashhad. 116. Nazarian, R., & Sahabi, H. (2018). Effect of Planting Density on Flower Quality in Two Types of Saffron (Crocus sativus L.). Journal of Saffron Research. 5:139–149. Mashhad: Iran. Ferdowsi University of Mashhad. 117. Negbi, M. (1999). Saffron cultivation: past present and future prospects. Harwood Academic Publishers. Australia. 154: 1-17. 118. Negbi, M.; Dagan,B.; Dror,A.; and Basker,D .(1989). Growth, flowering, vegetative reproduction and dormancy in the saffron crocus (Crocus sativus L.). Journal of Botany.38(2): 95–113.119. Nehvi, F.A., Lone, A.A., Khan M.A., and Maqhdoomi, M.I.(2010).Comparative Study on Effect of Nutrient Management on Growth and Yield of Saffron under Temperate Conditions of Kashmir. Acta horticulturae:850:165-170. Sher-e-Kashmir: India. University of Agricultural Sciences & Technology of Kashmir India. 120. Niazmand, R., and Ahmadian-Kouchaksaraie, Z.(2016). Extraction of effective compounds of saffron petals with the help of ultrasound waves and optimization of its extraction conditions. Journal of New Food Technologies.13: 121-135. Mashhad: Iran. Research Institute of Food Science and Technology. 121. Nickhah, E., Khayami, M., Heydari, R. (2010). Effect of some chemicals on stability of anthocyanins from blackberry (Morusnigra).25 (1): 32-43. Maragheh: Iran. Maragheh University of Medical Sciences. 122. Nijveldt, R.J., Van Nood, E., Van Hoorn, D.E., Boelens, P.G., Van Norren, K., Van Leeuwen, P.A. (2001). Flavonoids: a review of probable mechanisms of action and potential applications. Am. J. Clin. Nutr. 74(4):418-425. Amsterdam: Netherlands. Vrije Universiteit Medical Center. 123. Omidbaigi, R.(2005). Effects of corm weight on quality of Saffron (Crocus sativus L.). Indian Journal of Natural Products and Resourses. 4(3): 193-194. Tehran:Iran. University of Tarbiat modares. 124. Omidi, H.; Naghdi Badi, H.; Golzad, A.; Torabi, H.; and Footoukian, M. (2009).The effect of chemical and bio-fertilizer source of nitrogen on qualitive and quantitative of saffron (Crocus sativus L.). Journal Of Medicinal Plants, 2(30): 98-109. Shahed: Iran. Shahed University. 125. Orricelli, T., Avan, RYJ., Lbertini, IA., Enanzoni, EV., and Osseinzadeh, RH.( 2019). Morphological And Molecular Characterization Of Italian , Iranian And Spanish Saffron (Crocus sativus L .). Accessions. 17:1875–1887. Perugia :Italy.University of Perugia. 126. Özel,A.;Erden,K. and Demirbilek, T. )2017(. determination of optimum corm size for saffron (Crocus sativus L.) and corm yield under the harran plain conditions. ARPN Journal of Agricultural and Biological Science. 12: )7(:236-240. 127. Pazoki, A., Kariminejad, M., and Targhi, A F. (2017) Effect of Corm Density on Yield and Qualitative Traits of Saffron (Crocus sativus L.) under Different Urea and Biological Fertilizers in Shahr-e-Rey Region. Journal of Crop Ecophysiology.11(2). Tehran: Iran. Islamic Azad University. 128. Perez A .(1995). Analisis biometrico de los cormos de azafran de distintas poblaciones de la provincial de Albacete. Trabajo fin de carrera Ingenieria Tecnica Agricola, Universidad Castilla –La Mancha, Albacete, Espana. 129. Perez-Bueno M (1995). El azafran. Ed Mundi-Prensa, Madrid, Esparia de Albacete. Trabajo fin de carrera Ingenieria Tecnica Agricola، Universidad Castilla-La-Mancha, Albacete, Espana. 130. Polunin O, Smythies B (1981). Guia de campo de las flores de Espana, Portugaly Sudoeste de Francia.Ed. Omega, Barcelona. pp. 422-457131. Quettier, D., Gressier, B. Vasseur., J. Dine., T.Brunet., C. Luyckx., M. Cayin., J. Bailleul, F.,Trotin, F. (2000). Phenolic compounds and antioxidant activities of buck wheat (Fagopyrum esculentum Moench) hulls and flour. J. Ethnopharmacol. 72(1-2): 35-42. Lille Cedex: France. Faculté de Pharmacie. 132. Rees, AR. (1988). Saffron, an expensive plant product. The plantsman, 210-217. 133. Renau-Morata, B.; Moya, L.; Nebauer, S.; SeguiSimarro,G., Para-Vega, V.,Gomez, M. D. and Molina, R. V. (2013). The use of corms produced under storage at low temperatures as a source of explants for the in vitro propagation of saffron reduces contamination levels and increases multiplication rates, Ind. Crop Prod.46: 97-104. Valencia: Spain. University of Valencia. 134. Rezvani Moghaddam, P., Khorramdel, S., Amin Ghafori, A., and Shabahang, J., (2013a). Evaluation of growth and yield of saffron (Crocus sativus L.) affected by spent mushroom compost and corm density. Journal of Saffron Research. 1(1): 13-26. Mashhad:Iran. Ferdowsi University of Mashhad. 135. Rezvani Moghaddam, P., Koocheki, A., Molafilabi, A., Seyyedi, S.M.( 2013b). Effect of biological and chemical fertilizers on replacement corm and flower yield of saffron (Crocus sativus L.). Iran. J. Crop Sci. 15, 234–246. Mashhad:Iran. Ferdowsi University of Mashhad. 136. Rezvani Moghaddam, P., Mohammad-Abadi. A.A., Fallahi, H., and Shajari, M. (2014). Effect of nutritional management on flower yield and corm growth in cultivated saffron plant (Crocus sativus). Journal of Horticultural Science. 28(3): 427–434. Mashhad:Iran. Ferdowsi University of Mashhad. 137. Rostami Majid, Mohammadi Huda. (2013). Effect of planting date and corm density on growth and yield of saffron in climate of Malayer. Ecology of Agriculture. 1, 27-38.Malayer.Iran. Malayer university. 138. Roudbary, M, Roudbar Mohammadi, SH, Hajimoradi, M, Takhizadeh, M, Ghasemi Sakha, F and Vahidi, M.(2009). Evaluation of antifungal activity of alkoholic extract and safranol of Crocus sativus on Candida albicans and Candida dubliniensis growth in vitro. Journal of Jahrom Univercity of Medical Siences. 7(2).Tehran: Iran. Univercity of Tarbiat Modares. 139. Rubio-Moraga, Á, Gómez-Gómez, L, Trapero, A, Castro-Díaz, N and Ahrazem, O.(2013). Saffron corm as a natural source of fungicides: The role of saponins in the underground. Industrial Crops and Products. 49: 915-921. Albacete: Spain. Castilla La-Mancha University. 140. Sabet Teimouri, M., Kafi, M., Avarseji, A., & Orooji, K. (2010) Effect of drought stress, cormsize and corm tunic on morphoecophysiological characteristics of saffron (Crocus sativus L.) in greenhouse condition. Journal of Agroecology. 2 (2): 323-334. Mashhad:Iran .Ferdowsi University of Mashhad. 141. Sabzevari, S., Khazaie, H.R., and Kafi, M. (2010). Study on the effects of humic acid on germination of four wheat cultivars (Triticun aestivum L.). Journal of Iranian Field Crop Research. 8(3): 473-480. Mashhad: Iran. Ferdowsi University of Mashhad.142. Sadeghi, B., Negari, K., Hatami, M., (2003). Effect of planting date on saffron flowering. 3rd National Symposium on Saffron. 2–3 December, Mashhad, Iran. 143. Sanei, Sayed and Razavi, Syed.(2018). In vitro antifungal activities of saffron (Crocus sativus L.) stigmas against Aspergillus species and toxin production. Iranian Journal of Medicinal and Aromatic Plants. 34(1): 77-86. Gorgan: Iran. University of Gorgan. 144. Sani, A M, Kakhki, A H and Moradi, E. (2013). Chemical composition and nutritional value of saffron’s pollen (Crocus sativus L.). Nutrition & Food Science.43(5):490-495.Quchan, Iran.Islamic Azad University. 145. Sepaskhah, AR., & Kamgar-Haghighi, AA. (2009). Saffron Irrigation Regime. International Journal of Pant Production. 3(1):1-16. Shiraz: Iran. Shiraz University. 146. Sepehri, Zahra, Javadian, Fatemeh, Khammari, D and Hassanshahian, Mehdi.(2016). Antifungal effects of the aqueous and ethanolic leaf extracts of Echinophora platyloba and Rosmarinus officinalis .Curr Med Mycol. 2(1): 30-35. Zabol: Iran. University of Zabol. 147. Shahmansouri, N, Farokhnia, M, Abbasi, S-H, Kassaian, S E, Tafti, A-A, & Gougol, A. (2013). A randomized , double-blind , clinical trial comparing the efficacy and safety of (Crocus sativus L). with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patients. Journal of Affective Disorders:1–7.Tehran, Iran.Tehran University of Medical Sciences. 148. Shams, J., Molavi, S., Marjani, S., Kamalinejad, M., Sahraei, H., & Noroozzadeh, A. (2007). Reduction of morphine tolerance by the Crocus sativus extract in female mice as assessed by tail flick. Proceedings of 18th Iranian Congress of Physiology & Pharmacology. Mashad:Iran. pp: 78 – 9. 149. Sharifi, N, Hojjatoleslamy,M. and Jafari, M.,. (2016). Study of qualitative characteristics of saffron cultivated in different regions of Iran. Journal of Herbal Drugs.6(4):235-240. Shahrekord, Iran. Islami Azad University. 150. Shrififar, F., Moshafi, M.H.,and Mansouri, S.H. )2007(. In vitro evaluation of antibacterial and antioxidant of the essential oil and methanol extract of endemic Zatariamultiflora Boiss. Food Control. 18: 800-805. 151. Singh, J and Tripathi, N. N.(1999). Inhibition of storage fungi of blackgram (Vigna mungo L.) by some essential. Flavour Fragrance J. 14 (1): 14.Gorakhpur: India. University of Gorakhpur. 152. Sitara, U, Niaz, I, Naseem, J and Sultana, N.(2008). Antifungal effect of essential oils on In vitro growth of pathogenic fungi. Pakistan Journal of Botany. 40: 409-414. Karachi: Pakistan. Pakistan Agricultural Research Council. 153. Srivastava, R., Ahmed, H., Dixit, RK., Dharamveer, Saraf, S. A. (2010). Crocus sativus L.: A comprehensive review. Pharmacognosy Reviews. 4(8):200-208. Uttar Pradesh, India. Faculty of Pharmacy.154. Stankovic, M.S. (2011). Total Phenolic Content, Flavonoid concentration and antioxidant activity of Marrubium peregrinum L. extracts.Kragujevac J. Sci. 33: 63-72. Kragujevac, Republic of Serbia University of Kragujevac. 155. Tajik, S., Zarinkamar, F., and Niknam, V. (2017). Evaluation of antioxidant activity and determination of phenolic content of saffron organs. Biotechnology of Tarbiat Modarres University.8(3):127-138. Tehran: Iran. Tarbiat Modarres University. 156. Tammaro F. (1999). Saffron (Crocus sativus L.) in Italy, in. Harwood Academic Publishers, Australia, pp. 53–62. 157. Tavakkoli,A. Sorooshzade,A and Ghorbani Javid,M.(2013). Effect of buds removing and corm size on growth characteristics and yield of saffron (Crocus sativus L.). Saffron Agronomy & Technology. 1)2( :69-84 .Tarbiat Modares University, Tehran, Iran. 158. Termentzi, A., & Kokkalou, E. (2008). LC-DAD-MS (ESI+) analysis and antioxidant capacity of crocus sativus petal extracts. Planta Medica. 74: 573-581. Thessaloniki: Greece. Aristotle University of Thessaloniki. 159. Trabelsi, N., Falleh, H., Jallali, I., Ben Daly, A ., Hajlaoui, H ., Smaoui, A., Abdelly, C and Ksouri, R. (2012). Variation of phenolic composition and biological activities in Limoniastrum monopetalum L. organs. Acta Physiol Plant. 34:87–96. Monastir: Tunisia. Faculte´ de Pharmacie. 160. Turhan, H., Kahriman, F. ,Egesel, C.O. and KemalGul, M. (2007). The effects of different growing media on flowering and corm formation of saffron (Crocus sativus L.). African Journal of Biotechnology . 6 (20):2328-2332. 17020-Canakkale: Turkey. Canakkale Onsekiz Mart University. 161. Unal, M., and Cavusoglu, A. (2005). The effect of various nitrogen fertilizers on saffron (Crocus sativus L.) yiled. Akdeniz Universitesi Ziraat Fakultesi Dergisi. 18(2): 257-260. Kocaeli: Turkey. Kocaeli University. 162. Vo, T.S., Chau Vo, T.T.B. and Ngoc Vo, T. T.T.(2021). Characterization and health effects of saffron in disease treatment and prevention: a review.J Res Clin Med. 9: 28. 1-10. Suwon: Korea. Sungkyunkwan University.. 163. Wali, Adil, Abou Alchamat, Houda, Hariri, Huda, Hariri, Bushra, Menezes, Godfred, Zehra, Uzma, Rehman, Muneeb and Ahmad, Parvaiz.(2020). Antioxidant, Antimicrobial, Antidiabetic and Cytotoxic Activity of Crocus sativus L. Petals. Appl. Sci., 10(1519):1-12. Riyadh: Saudi Arabia. King Saud University. 164. Yang, X.; Chen,X.; Fu, Y.; Luo, Q. ; Du, L; H. Qiu; H., Qiu,T.; Zhang ,L. and Meng,H. (2018). Comparative efficacy and safety of Crocus sativus L. for treating mild to moderate major depressive disorder in adults: a meta-analysis of randomized controlled trials. Neuropsychiatric Disease and Treatment , 14: 1297-1305. Chongqing: China. The First Affilated Hospital of Chongqing Medical University. 165. Yazdani, D, Tan, H.Y., Zainal Abidin, M and Jaganath, I.(2011). A review on bioactive compounds isolated from plants against plant pathogenic fungi. Journal ofMedicinal Plants Research. 5: 6584-6589. Serdang: Malaysia. Universiti Putra Malaysia. 166. Zabihi, H R. (2017). Plant nutrition management in saffron.Technical journal. 555(1):1-19.Khorasan: Iran.Ministry of Agriculture. 167. Zargari, A. (1981). Medicinal Plants. University of Tehran Publication. 574 p. 168. Zeka, Keti, Ruparelia, Ketan, Continenza, Maria, Stagos, Dimitrios, Vegliò, Francesco and Arroo, Randolph.(2015). Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol. Fitoterapia.107:128-134. L'Aquila: Italy. University of L'Aquila.