Application of the comet assay in the evaluation of the semi-synthetic n-butyl dillapiole ether in Balb/C mice.
2022
CRUZ, D. L. V. | PINTO, A. C. da S. | MATOS, L. B. | CHAVES, F. C. M. | VASCONCELOS, N. S. de | GOMES JÚNIOR, P. P. | RAFAEL, M. S. | DANIEL LUÍS VIANA CRUZ, BOLSISTA CPAA; ANA CRISTINA DA SILVA PINTO, BOLSISTA CPAA; LEONARDO BRANDÃO MATOS, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; FRANCISCO CELIO MAIA CHAVES, CPAA; NEIVA SILVA DE VASCONCELOS, BOLSISTA CPAA; PLÍNIO PEREIRA GOMES JÚNIOR, FAZENDA SACO; MÍRIAM SILVA RAFAEL, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA.
The semi-synthetic n-butyl ether dillapiole (EBD) has a potential effect on the control of Aedes aegypti, the vector of the dengue, Zika, chikungunya, and yellow fever virus. However, there are no studies on the risk of exposure to this compound to the health of humans and other animals. In this sense, the Comet Assay Test is used to detect genomic lesions that can result in mutations. Objective: evaluate the incidence of DNA damage in blood cells of isogenic mice treated with EBD.
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