Medicinal Plants Reduce Neurodegeneration and Improve Memory in Induced Alzheimer’s Disease in Rat Model

Alzheimer’s disease (AD) is a devastating and debilitating neurological brain disorder that has a multifactorial nature associated with complex pathophysiology. Thus, concerns directed to develop alternative therapies which possess multifaceted action for treatment of AD. This article was aimed to compare efficacy of Moringaolifera (MO), ginkgo biloba (GB) and green tea (GT) extracts in managing induced Alzheimer’s disease in albino rat using behavioural, biochemical, and pathological alterations. Eighty five male Wistar rats weighing 80-120g were randomly divided into five groups (17 rats for each). Control (administered with distilled water), Alzheimer disease model (ADM, administered with AlCl3), ADM + MO (administered with AlCl3 and ethanolic extract of MO), ADM + GB (administered with AlCl3 and ethanolic extract of GB), and ADM + GT (administered with AlCl3 and ethanolic extract of and ethanolic extract of MO), ADM + GB (administered with AlCl3 and ethanolic extract of GB), and ADM + GT (administered with AlCl3 and ethanolic extract of GT). All treatments were administered daily by oral gavage and persisted for seventy consecutive days. On the 60th day of the experiment, all memory tests were performed. Then the rats were humanely sacrificed using diethyl ether anesthesia, and brain samples were collected.  Treatments with MO, GB, or GT successfully rescue Neuro-therapeutic abilities against AD. In addition, the used treatments restore the rats’ memory and cognitive performances in the Y-maze, novel objective recognition and Morris Water maze testes. In Conclusion, MO, GB, or GT may provide a more effective strategy to lessen neurodegeneration in AD.