Isotope tracers in metabolic research
2005
Wolfe, Robert R. | Chinkes, David L.
This book offers the most thorough practical and theoretical treatment of tracer methodology as applied to the study of metabolic processes. It integrates biochemical, physiological, mathematical, and analytical aspects, with a focus on radioactive and stable isotopes in biomedical research. The authors systematically present complete information on how to perform these studies, from tracer selection, modeling considerations, sample derivitization, mass spectrometry analysis, and data interpretation. Problems and discussion questions have been added to highlight key points in each chapter. The contents have been fully updated and reorganized to enhance its utility, with notable expansion of coverage on protein metabolism and a brand new chapter on nuclear magnetic resonance (NMR).
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