The response of cyclic nucleotide content in liver and brown fat of rats weaned to different diets
1980
Hahn, P. | Skala, J.P. | Hassanali, S.
Premature weaning to different diets affects the cyclic nucleotide levels in rat liver and, to some extent, also in brown fat. After 24 hours for rats aged 31 days, hepatic levels of cyclic guanosine 3',5'-monophosphate and adenosine 3',5'-cyclic monophosphate were higher in males fed the high-fat diet than those fed the high-carbohydrate diet. Rats weaned prematurely (day 18) reacted the same way. Either diet resulted in higher hepatic cyclic nucleotide levels than in rats kept with the dam. The atherogenic diet showed least effect in raising these levels. After fasting cyclic nucleotide levels in liver and brown fat were elevated; hepatic levels could not be lowered by 6 hours of feeding the high-fat or atherogenic diets. Feeding male 40-day-old rats for 2 hours did lower these levels, more so with a high-carbohydrate than a high-fat diet. The data suggest that in addition to blood hormone levels, other factors play a role in regulating cyclic nucleotide levels.
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