TLR5 Stops Commensals in Their Tracks

Koch, Meghan A.; Barton, Gregory M.

TLR5 Stops Commensals in Their Tracks

2013

Koch, Meghan A. | Barton, Gregory M.

IgA antibodies help maintain intestinal immune homeostasis with resident commensal species; however, the precise mechanisms regulating IgA induction and the epitopes recognized by these antibodies remain incompletely understood. In this issue of Cell Host & Microbe, Cullender et al. (2013) demonstrate that TLR5-dependent induction of anti-flagellin antibodies prevents commensal association with the intestinal mucosa by limiting bacterial motility.

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