Convenient synthesis of carbamates, S-alkyl thiocarbamates, and N,N′-disubstituted urea derivatives of methoxycarbonylsulfenyl isocyanate

Torrico-Vallejos, Sonia; Erben, Mauricio F.; Hey-Hawkins, Evamarie; Della Védova, Carlos O.

Convenient synthesis of carbamates, S-alkyl thiocarbamates, and N,N′-disubstituted urea derivatives of methoxycarbonylsulfenyl isocyanate

2011

Torrico-Vallejos, Sonia | Erben, Mauricio F. | Hey-Hawkins, Evamarie | Della Védova, Carlos O.

Convenient simple and suitable methods for the synthesis of carbamates, N,N′-unsymmetrically disubstituted ureas, and S-alkyl thiocarbamates derived from CH₃OC(O)SNCO in one-step are provided. Reactions are operationally simple and have high selectivity toward nitrogen, oxygen, and sulfur nucleophiles. The absence of solvents coupled with high yields and short reaction times make these procedures very attractive for synthesis.

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