Structural Characterization of Lecithin-Stabilized Tetracosane Lipid Nanoparticles. Part I: Emulsions
2016
Schmiele, M. | Busch, S. | Morhenn, H. | Schindler, T. | Schmutzler, T. | Schweins, R. | Lindner, P. | Boesecke, P. | Westermann, M. | Steiniger, F. | Funari, Sérgio S. | Unruh, T.
The structure of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)-stabilized colloidal tetracosane emulsions was investigated by photon correlation spectroscopy and small-angle X-ray and neutron scattering, using emulsions with different neutron scattering contrasts. Special emphasis was placed on the structure of the DMPC stabilizer layer covering the emulsion droplets. A monolayer, structurally similar to a half DMPC bilayer, with a thickness of 16 Å is found. Thereby, the phosphocholine headgroups arrange flat at the oil–water interface. A deep penetration of the tetracosane oil into the stabilizer layer can be ruled out.
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