The effect of chronic diazepam administration on lipid peroxidation and Ca <sup>2+</sup> -ATPase activity in rat liver
2007
Seçkin, Şule | Alsancak, Şeyda | Başaran-Küçükgergin, Canan | Uysal, Müjdat
Chronic administration of diazepam (DZP) caused an increase in malondialdehyde (MDA) levels and a decrease in glutathione (GSH) content. DZP also markedly lowered Ca <sup>2+</sup> ATPase activity. Treatment with Se plus vitamin E reduced MDA levels and increased GSH content. Our results suggest that, increased lipid peroxidation together with alteration in Ca <sup>2+</sup> -ATPase activity may play a role in DZP induced hepatic injury and Se plus vitamin E treatment may contribute to the attenuation of DZP induced hepatotoxicity.
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