A new prenylated indole derivative from endophytic actinobacteria Streptomyces sp. neau-D50
2014
Zhang, Ji | Wang, Ji-Dong | Liu, Chong-Xi | Yuan, Jia-Hui | Wang, Xiang-Jing | Xiang, Wen-Sheng
A new prenylated indole derivative 3-acetonylidene-7-prenylindolin-2-one (1) was isolated from the endophytic actinobacterium Streptomyces sp. neau-D50, together with four known hybrid isoprenoids, 7-isoprenylindole-3-carboxylic acid (2), 3-cyanomethyl-6-prenylindole (3), 6-isoprenylindole-3-carboxylic acid (4) and 7,4′-dihydroxy-5-methoxy-8-(γ,γ-dimethylallyl)-flavanone (5). The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis and comparison with data from the literature. Compounds 1 and 2 demonstrated strong cytotoxic activities against human lung adenocarcinoma cell line A549 with an IC ₅₀ of 3.3 and 5.1 μg mL ⁻ ¹, respectively, which are comparable to that of the positive control doxorubicin (4.2 μg mL ⁻ ¹). Furthermore, compounds 1 – 4 exhibited potent antifungal activity against phytopathogenic fungi Colletotrichum orbiculare , Phytophthora capsici, Corynespora cassiicola and Fusarium oxysporum .
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