A comparison of essential and general amino acid infusions in protein-depleted patients receiving parenteral alimentation
1979
Wassner, Steven J. | Sanders, Richard | Orloff, Sheldon | Sheldon, George F. | Holliday, Malcolm A. (Malcolm Alexander)
Six malnourished patients were studied during intravenous nutrition therapy to compare the efficiency of essential and general amino acids when given at a rate of 2.0 g of amino acids per 100 kcal. The study also determined if nitrogen retention could be supported at the calorie and nitrogen levels chosen for infusion, and which of the two solutions would be utilized more efficiently. A cross-over design was used so that each patient received essential amino acids (EAA) plus arginine and histidine and a general amino acid (GAA) solution in random order. Each patient's daily urea nitrogen production increased during infusion of the GAA solution, and nitrogen intake minus urea nitrogen production was greater with the EAA solution. Plasma amino acid levels were also determined during infusion of both EAA and GAA, but the results were complicated by the infusion of different quantities of amino acids and their infusion by vein rather than by portal circulation. The experimental protocol may be useful as a low-cost screening device in clinical settings to test the efficiency of a new amino acid solution against a standard one.
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