Immunoribosomes: Where’s there’s fire, there’s fire
2019
Wei, Jiajie | Yewdell, Jonathan W.
The MHC class I antigen presentation pathway enables T cell immunosurveillance of cancer cells, viruses and other intracellular pathogens. Rapidly degraded newly synthesized proteins (DRiPs) are a major source of self-, and particularly, viral antigenic peptides. A number of findings support the idea that a substantial fraction of antigenic peptides are synthesized by “immunoribosomes”, a subset of translating ribosomes that generate class I peptides with enhanced efficiency. Here, we review the evidence for the immunoribosome hypothesis.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
出版者
Elsevier Inc.
其它主题
Neoplasm cells; Mhc-i; Antigen presentation; Drips; Immunosurveillance; Immunoribosomes
语言
英语
类型
Journal Article; Text
2024-02-27
MODS