Transgenic mice with I-A on islet cells are normoglycemia but immunologically intolerant
1989
Bohme, J. | Haskins, K. | Stecha, P. | Van Ewijk, W. | LeMeur, M. | Gerlinger, P. | Benoist, C. | Mathis, D.
Insulin-dependent diabetes mellitus (IDDM) is caused by a specific loss of the insulin-producing beta cells from pancreatic Langerhans islets. It has been proposed that aberrant expression of major histocompatibility complex (MHC) class II molecules on these cells could be a triggering factor for their autoimmune destruction. This proposal was tested in transgenic mice that express allogeneic or syngeneic class II molecules on the surface of islet cells at a level comparable with that normally found on resting B lymphocytes. These animals do not develop diabetes, nor is lymphocyte infiltration of the islets observed. This immunological inactivity does not result from tolerance to the "foreign" class II molecules.
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