Effects of adjuvant-induced arthritis on the ventral prostate of rats treated with angiotensin AT1 receptor blocker
2020
da Rocha, Emerson Souza | Gomes, Fabiana de Campos | de Oliveira, Murilo Romano | Bruneto, Ricardo Vinicius | Borges, Rodrigo Miranda Ramos | de Carvalho, Enzo Prandi | Angeli-Junior, Euradir Vitório | Garcia-Filho, Glayber Falcão | Doná, João Pedro Lot | de Oliveira Batanero, Rodrigo Piloto | Carlos, Carla Patrícia | de Melo-Neto, João Simão
To analyze the prostatic compartments, extracellular matrix, microvascularization, transforming growth factor-beta (TGF-β) and angiotensin II receptors type 1 (AT₁) levels, and histopathology of the ventral prostate in a rat model for rheumatoid arthritis, and to evaluate the effect of angiotensin II AT₁ receptor blocker (ARB) in the disease.Fifteen male rats (90 days old) were divided into three groups (n = 5/group): control, adjuvant-induced arthritis without (AIA) or with AT₁ receptor blocker (AIA + ARB). Animals were euthanized 60 days after immunization. The ventral prostate was collected, weighed, and processed for histological and immunohistochemical analysis.Our results show that AIA increases production of the prostatic epithelium and extracellular matrix, accompanied by a reduction in the number of tissue capillaries. ARB treatment promotes decreased production of extracellular matrix and increased TGF-β and AT₁ receptor immunostaining.AIA may activate specific mechanisms that modify the prostatic environment; the use of ARB attenuates some altered prostate parameters in a rat model for arthritis.
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