Biologically active metabolites of the facultative marine fungus Penicillium citrinum
2013
Yurchenko, A. N. | Smetanina, O. F. | Kalinovskii, A. I. | Kirichuk, N. N. | Yurchenko, E. A. | Afiyatullov, Sh. Sh
Four sesquiterpenoid metabolites, JBIR-27, petasol, sporogen AO-1, and dihydrosporogen AO-1, that were previously unknown for Penicillium citrinum were isolated from the marine isolate of this fungus. The structures of the compounds were established using NMR spectral data and high-resolution mass spectrometry. It was shown that sporogen AO-1 exhibited weak antimicrobial and cytotoxic properties. Cytotoxic action was observed for dihydrosporogen AO-1 against Ehrlich carcinoma cells (ED₅₀ 0.4 mM).
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