Effect of cigarette smoking and dietary vitamin E on plasma level of vitamin C in rats
1980
Chen, L.H. | Chow, C.K.
Weanling rats fed a vitamin E and C-free diet for 5 weeks with or without vitamin E supplementation, were exposed to either 2 levels of cigarette smoke or sham controls for 3 or 7 days. Cigarette smoking significantly decreased plasma vitamin C levels in both dietary groups at the higher level of exposure. At the lower level of exposure, cigarette smoking for 3 days significantly decreased plasma vitamin C in the vitamin E-deficient animals; 7 day exposure reduced vitamin C levels in both dietary groups. Cigarette smoking had no effect on plasma levels of vitamin E in these experiments. These findings inplicate cigarette smoking in depletion of plasma vitamin C; dietary intakes of vitamin E, however, may have a sparing effect on vitamin C levels, thus counteracting the effect of cigarette smoking.
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