Borrelia burgdorferi Complement Regulator-Acquiring Surface Protein 1 of the Lyme Disease Spirochetes Is Expressed in Humans and Induces Antibody Responses Restricted to Nondenatured Structural Determinants
2006
Rossmann, Evelyn | Kitiratschky, Veronique | Hofmann, Heidelore | Kraiczy, Peter | Simon, Markus M. | Wallich, Reinhard
Borrelia burgdorferi complement regulator-acquiring surface protein 1 (CRASP-1), the dominant factor H and FHL-1-binding protein of the Lyme disease spirochete B. burgdorferi, is implicated in pathogen persistence and was recently reported to be nonimmunogenic in humans. Here we show that serum samples from Lyme disease patients contain antibodies with exclusive specificity for nondenatured structural determinants of CRASP-1.
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书目信息
出版者
Elsevier Ltd
其它主题
Epitopes; Pathogen survival; Bacterial; Complement; Membrane proteins; Surface proteins
语言
英语
注释
Includes references
许可
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类型
Journal Article; Text
2024-02-27
MODS