Saikosaponin derivatives from Bupleurum wenchuanense
1993
Luo, S.Q. | Lin, L.Z. | Cordell, G.A.
From the roots of Bupleurum wenchuanense 14 derivatives of saikosaponin were isolated and identified as 2''O-beta-D-xylopyranosylsaikosaponin b2, 3'',6''-O,O-diacetylsaikosaponin b2, 2''-O-beta-D-glucopyranosylsaikosaponin b2, saikosaponin b2, 6''-O-acetylsaikosaponin b2, saikosaponin d, 2''-O-acetylsaikosaponin d, 3''-O-acetylsaikosaponin d, 6''-O-acetylsaikosaponin d, 16-epichikusaikoside, prosaikogenin G, saikosaponin a, 2''-O-acetylsaikosaponin a and 3''-O-acetylsaikosaponin a. The first two compounds are new derivatives of saikosaponin and this is the first isolation of prosaikogenin G from a plant. Their complete 1H and 13C NMR assignments were made by using a combination of 2D NMR techniques (DQF-COSY, HOHAHA, ROESY, HETCOR, HMQC and HMBC). Some of the compounds showed cytotoxic activity against the P-388 cell line.
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