Electro-oxidative cyclization: access to quinazolinones via K₂S₂O₈ without transition metal catalyst and base
2021
Hu, Yongzhi | Hou, Huiqing | Yu, Ling | Zhou, Sunying | Wu, Xianghua | Sun, Wei M. (Wei Ming) | Ke, Fang
A K₂S₂O₈-promoted oxidative tandem cyclization of primary alcohols with 2-aminobenzamides to synthesize quinazolinones was successfully achieved under undivided electrolytic conditions without a transition metal and base. The key feature of this protocol is the utilization of K₂S₂O₈ as an inexpensive and easy-to-handle radical surrogate that can effectively promote the reaction via a simple procedure, leading to the formation of nitrogen heterocycles via direct oxidative cyclization at room temperature in a one-pot procedure under constant current. Owing to the use of continuous-flow electrochemical setups, this green, mild and practical electrosynthesis features high efficiency and excellent functional group tolerance and is easy to scale up.
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