C–C Bond Formation via Copper-Catalyzed Conjugate Addition Reactions to Enones in Water at Room Temperature
2012
Lipshutz, Bruce H. | Huang, Shenlin | Leong, Wendy Wen Yi | Isley, Nicholas A.
Conjugate addition reactions to enones can now be done in water at room temperature with in situ generated organocopper reagents. Mixing an enone, zinc powder, TMEDA, and an alkyl halide in a micellar environemnt containing catalytic amounts of Cu(I), Ag(I), and Au(III) leads to 1,4-adducts in good isolated yields: no organometallic precursor need be formed.
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书目信息
Journal of the American Chemical Society
卷
134
期
49
页码
19985
- 19988
ISSN
1520-5126
出版者
American Chemical Society
其它主题
Chemical bonding; Ambient temperature
语言
英语
许可
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类型
Text; Journal Article
2024-02-27
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