N-Cyanation of Secondary Amines Using Trichloroacetonitrile
2016
Ayres, James N. | Ling, Kenneth B. | Morrill, Louis C.
A one-pot N-cyanation of secondary amines has been developed using trichloroacetonitrile as an inexpensive cyano source. A diverse range of cyclic and acyclic secondary amines can be readily transformed into the corresponding cyanamides in good isolated yields, with the method successfully utilized in the final synthetic step of a biologically active rolipram-derived cyanamide. This approach exhibits distinct selectivity when compared to the use of highly toxic cyanogen bromide.
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书目信息
Organic letters
卷
18
期
21
页码
5528
- 5531
ISSN
1523-7052
出版者
Elsevier Science
其它主题
Cyanogen; Secondary amines
语言
英语
类型
Journal Article; Text
2024-02-27
MODS