A Three-Compartment Chemically-Driven Molecular Information Ratchet

Carlone, Armando; Goldup, Stephen M.; Lebrasseur, Nathalie; Leigh, David A.; Wilson, Adam

A Three-Compartment Chemically-Driven Molecular Information Ratchet

2012

Carlone, Armando | Goldup, Stephen M. | Lebrasseur, Nathalie | Leigh, David A. | Wilson, Adam

We describe a three-compartment rotaxane information ratchet in which the macrocycle can be directionally transported in either direction along an achiral (disregarding isotopic labeling) track. Chiral DMAP-based catalysts promote a benzoylation reaction that ratchets the displacement of the macrocycle, transporting it predominantly to a particular end compartment determined by the handedness of the catalyst.

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