Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl)alkylphosphonate esters
2017
Adeyemi, Christiana M. | Isaacs, Michelle | Mnkandhla, Dumisani | Klein, Rosalyn | Hoppe, Heinrich C. | Krause, Rui W.M. | Lobb, Kevin A. | Kaye, Perry T.
Unexpected substituent-dependent regioselectivty challenges in the synthesis of C-benzylated (N-arylcarbamoyl)phosphonate esters have been resolved. The C-benzylated N-furfurylcarbamoyl derivative showed low micromolar PfLDH inhibition, while one of the C-benzylated N-arylcarbamoyl analogues was active against Nagana Trypanosoma brucei parasites which are responsible for African trypanosomiasis in cattle.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
出版者
Springer Berlin Heidelberg
其它主题
C-benzylation; Michaelis-arbuzov reaction; Antiparasitic properties; Phosphonate esters; Bovine trypanosomiasis; 2-halogeno-3-phenylpropanoic acid; Anti-parasitics
语言
英语
类型
Journal Article; Text
2024-02-27
MODS