Extraction, identification and antimicrobial activity of a new furanone, grifolaone A, from Grifola frondosa
2016
He, Xiaoyun | Du, Xuezhu | Zang, Xiangyun | Dong, Lili | Gu, Zijian | Cao, Liping | Chen, Dafu | Keyhani, Nemat O. | Yao, Lindan | Qiu, Junzhi | Guan, Xiong
A furanone (1), (S)-methyl 2-(2-hydroxy-3,4-dimethyl-5-oxo-2,5-dihydrofuran-2-yl)acetate, was isolated from the edible mushroom Grifola frondosa . Mass spectrometry and NMR analyses were used to elucidate the structure of this compound, and its absolute configuration was determined using circular dichroism spectroscopy. Compound 1 exhibited specific antifungal activity against the plant pathogens, Fusarium oxysporum , Gibberella zeae and Piricularia oryzae and the opportunistic human pathogen, Pseudallescheria boydii , resulting in minimum inhibitory concentration values of 2.5, 2.5, 1.25 and 0.15 μg/mL, respectively. In contrast, the furanone showed only weak activity towards Aspergillus spp., Candida albicans and several other fungal strains tested as well as no appreciable antibacterial activity.
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