Synthesis of 3-amino-3,4-dihydro-1H-quinolin-2-ones through regioselective palladium-catalyzed intramolecular cyclization
2016
Hallé, François | Van der Poorten, Olivier | Doebelin, Christelle | Niederst, Marie | Schneider, Séverine | Schmitt, Martine | Ballet, Steven | Bihel, Frédéric
In this Letter we explored the regioselective cyclization of 2-bromophenylalanine derivatives to access enantiopure dihydroquinolinones via an intramolecular regioselective Buchwald–Hartwig cyclization using Pd2(dba)3/XPhos as a catalytic system in the presence of BTPP as organic base. This procedure represents a promising strategy for the direct synthesis of bridged Phe-Xaa dipeptides.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
出版者
Elsevier Ltd
其它主题
Dihydroquinolinone; Btpp; Buchwald–hartwig; Enantiomers; Bridged peptide; Indoline
语言
英语
类型
Journal Article; Text
2024-02-27
MODS