Organosilicon-mediated regioselective acetylation of carbohydrates
2012
Zhou, Yixuan | Ramström, Olof | Đông Hải,
Organosilicon-mediated, regioselective acetylation of vicinal- and 1,3-diols is presented. Methyl trimethoxysilane or dimethyl dimethoxysilane was first used to form cyclic 1,3,2-dioxasilolane or 1,3,2-dioxasilinane intermediates, and subsequent acetate-catalyzed monoacylation was efficiently performed by addition of acetic anhydride or acetyl chloride under mild conditions. The reaction exhibited high regioselectivity, resulting in the same protection pattern as in organotin-mediated schemes.
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书目信息
出版者
SAGE Publications
其它主题
Acetic anhydride; Regioselectivity; Chemical communication
语言
英语
类型
Journal Article; Text
2024-02-27
MODS