Sigesbeckia K and L, two new diterpenoids from Sigesbeckia glabrescens with anti-inflammatory activity
2022
Hu, GaoSheng | Gao, Xiaoxu | Wang, Dongdong | Long, GuoQing | Jia, Jingming | Wang, Anhua
A chemical investigation of Sigesbeckia glabrescens Makino identified four compounds. On the basis of spectroscopic data, they were determined to be ent-pimarane-type diterpenoids and their analogues, among which were two previously undescribed compounds, Sigesbeckia K (1) and Sigesbeckia L (2). The anti-inflammatory effects of these compounds were evaluated by testing their inhibition of LPS-induced NO production in BV2 microglial cells, which revealed potential inhibitory effects with IC₅₀ value at 62.56 μM and compared with the positive control minocycline (IC₅₀ 32.84 μM).
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