Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation
2017
Tuan Anh, Hoang Le | Tuan, Do Thanh | Trang, Do Thi | Tai, Bui Huu | Nhiem, Nguyen Xuan | Yen, Pham Hai | Kiem, Phan Van | Minh, Chau Van | Duc, Tran Minh | Kang, Hee Kyoung | Kim, Youn Chul | Kim, Young Ho
Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata . At the concentration of 10 μM, compounds 1 , 2 , and 4 significantly inhibited NO production with the inhibitory values of 72.5 ± 2.4, 66.9 ± 1.8, and 55.4 ± 2.7%, respectively. In addition, all of isolated compounds 1–9 showed promising cytotoxic effects toward HL-60 cells (IC ₅₀ 4.3 ± 0.7 to 18.0 ± 1.7 μM).
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