Quinic acid esters from Pluchea indica with collagenase, MMP-2 and MMP-9 inhibitory activities
2008
Ohtsuki, Takashi | Yokosawa, Emiko | Koyano, Takashi | Preeprame, Srisomporn | Kowithayakorn, Thaworn | Sakai, Shinobu | Toida, Toshihiko | Ishibashi, Masami
Investigation of collagenase inhibitory natural components afforded two quinic acid esters (1 and 2) and quercetin (3) from the leaves of Pluchea indica (Compositae). Of these, compounds 1 and 2 exhibited collagenase inhibitory activity (IC₅₀) at a concentration of less than 10 μm, and 1 showed matrix metalloproteinase (MMP)-2 and -9 inhibitory activity (IC₅₀) at 2.5 and 6.4 μm, respectively.
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书目信息
Phytotherapy research
ISSN
0951-418X
出版者
Multidisciplinary Digital Publishing Institute
其它主题
Quinic acid; Quinic acid; Pluchea; Interstitial collagenase; Molecular structure; Matrix metalloproteinase inhibitors; Drug; Dose-response relationship
语言
英语
注释
Includes references
类型
Journal Article; Text
2024-02-27
MODS