Inactivation of Ascaris suum by Short-Chain Fatty Acids
2011
Butkus, Michael A. | Hughes, Kelly T. | Bowman, Dwight D. | Liotta, Janice L. | Jenkins, Michael B. | Labare, Michael P.
Ascaris suum eggs were inactivated in distilled water and digested sludge by butanoic, pentanoic, and hexanoic acids. The fatty acids (short-chain fatty acids [SCFA]) were effective only when protonated and at sufficient concentrations. The conjugate bases were not effective at the concentrations evaluated. Predictions from an inhibition model (50% inhibitory concentration [IC₅₀]) based on quantitative structure-activity relationships were congruent with inactivation data.
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